Ex parte TS'O et al. - Page 2




          Appeal No. 1995-3147                                                        
          Application No. 07/946,023                                                  


                                 DECISION ON APPEAL                                   
               This appeal was taken from the examiner's decision                     
          rejecting claims 31, 32 and 36 through 38, which are all of                 
          the claims remaining in the application.                                    
               Claims 32 and 38 are representative:                                   
               32.  A method of treating HSV-2 infection which comprises              
          administering intranasally to a host subject to said infection              
          an effective amount of a ribosyl polyinosinic                               
          acid@polycytidylic acid-polyuridylic acid copolymer.                        
               38.  A therapeutic composition for treating viral                      
          diseases by enhancing immunological protection by increasing                
          natural killer cell activity in an animal in need thereof                   
          comprising a polynucleotide of the formula polyrI@polyr(C U),               
                                                                   12                 
          an antibacterial, antifungal compound, and an inorganic salt                
          for maintaining the intactness of said polynucleotide, said                 
          salt being sodium chloride, potassium chloride or magnesium                 
          chloride.                                                                   
               The references relied on by the examiner are:                          
          Chain et al. (Chain)               3,975,520        Aug. 17, 1976           
          Ishida et al. (Ishida)             3,980,776        Sep. 14, 1976           
          Ts'o et al. (Ts'o)                 4,024,222        May  17, 1977           
          Bernstein et al. (Bernstein)       4,603,131        Jul. 29, 1986           
          Klaus Munk et al. (Munk), 77 Chemical Abstracts no. 32470j,                 
          356 (1972)                                                                  
          The Merck Index:  An Encyclopedia of Chemicals and Drugs 137,               
          270, 1202 (9th ed., Merck & Co., Inc., New Jersey 1976)                     
               The appealed claims stand rejected as follows:  (1)                    
          claims 37 and 38 under 35 U.S.C. § 112, first paragraph, as                 

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