Appeal No. 1995-4370 Application 07/401,432 would lead one skilled in the art to substitute amide bridges of the particular structure required by the claims for the disulfide binds of the prior art analogs. It is well settled that the initial burden of establishing unpatentability rests on the examiner. In re Oetiker, 977 F.2d 1443, 1446, 24 USPQ2d 1443, 1445 (Fed. Cir. 1992). Moreover, 35 U.S.C. § 103 requires that obviousness be determined on the basis of the claimed “subject matter as a whole.” Here, the examiner’s decisional process did not begin with a fact-based analysis of what was being claimed. The inevitable result was that the examiner’s conclusion of obviousness was based on less than the entire claimed subject matter. Accordingly, we find that the examiner’s initial burden of establishing a prima facie case of obviousness has not been met, and the 2 rejection of claims 29, 30, 86 and 87 under 35 U.S.C. § 103 is reversed. REVERSED ) William F. Smith ) Administrative Patent Judge ) ) ) BOARD OF PATENT Joan Ellis ) Administrative Patent Judge ) APPEALS AND ) ) INTERFERENCES 2Having determined that a prima facie case of obviousness has not been established, we do not find it necessary to comment on appellants’ arguments at pages 7 through 13 of the Brief regarding unexpected results attributable to the present invention. 6Page: Previous 1 2 3 4 5 6 7 8 NextLast modified: November 3, 2007