Appeal No. 1996-0927
Application 07/888,203
22. A method for homing hematopoietic stem cells to transplanted bone marrow
stromal cells and inducing proliferation of those stem cells in a host, comprising
administering to the host stromal cells genetically engineered to express a first
member of a ligand-receptor binding pair, and subsequently
administering to the host hematopoietic stem cells genetically engineered to
express a second member of said ligand-receptor binding pair, whereby binding of said
first member to said second member homes said stem cells to said stromal cells and
induces proliferation of said stem cells.
The references relied upon by the examiner are:
Anklesaria et al. (Anklesaria), "Engraftment of a Clonal Bone Marrow Stromal Cell Line in
vivo Stimulates Hematopoietic Recovery from Total Body Irradiation," Proceedings of the
National Academy of Science, Vol. 84, pages 7681-7685, 1987.
Ohkawa et al. (Ohkawa), "Effect of Direct Cell-to-Cell Interaction between the KM-102
Clonal Human Marrow Stromal Cell Line and the HL-60 Myeloid Leukemic Cell Line on the
Differentiation and Proliferation of the HL-60 Line," Cancer Research, Vol. 47, pages
2879-2882, 1987.
Pierce et al. (Pierce), "Signal Transduction Through the EGF Receptor Transfected in IL-3-
Dependent Hematopoietic Cells," Science, Vol. 239, pages 628-631, 1988.
Grounds of Rejection
Claims 3-9 and 22-23 stand rejected under 35 U.S.C. § 103. As
evidence of obviousness, the examiner relies on Anklesaria, Ohkawa and Pierce.
We reverse.
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