Ex Parte COPELAND et al - Page 3


               Appeal No. 96-1447                                                                                               
               Application 08/028,764                                                                                           

               respect to the latter statutory provision, we observe that while Adler would have reasonably                     
               suggested to one of ordinary skill in this art that the addition of membrane fragments to “many                  
               industrial fermentation processes” (col. 6, lines 1-3) which can contain “ethanol” (col. 4, line 67),            
               such addition would have been directly into the medium (e.g., col. 4, lines 62-64).  The examiner                
               has failed to provide evidence and/or scientific reasoning in the record explaining why one of                   
               ordinary skill in this art would have modified this teaching of Adler by incorporating the                       
               membrane fragments into a solution contacting surface of a fermentation vessel.5  Thus, it is                    
               manifest that the only direction to appellants’ claimed invention as a whole on the record before                
               us is supplied by appellants’ own specification.  Fine, supra; Dow Chem., supra.                                 















               fragments into the solution contact surface.  In re Morris, 127 F.3d 1048, 1054-56, 44 USPQ2d                    
               1023, 1027-29 (Fed. Cir. 1997); In re Zletz, 893 F.2d 319, 321-22, 13 USPQ2d 1320, 1322 (Fed.                    
               Cir. 1989).  Our reference to the specification is with respect to the substituted specification, filed          
               January 19, 1994 (Paper No. 14), entered by the examiner as set forth in the final rejection of                  
               May 11, 1994 (Paper No. 15). See also page 3 of the answer.  The objection with respect to the                   
               substitute specification (answer, page 3) is petitionable and not subject to review on appeal.                   
               Manual of Patent Examining Procedure § 706.01 (7th. ed., July 1998; 700-9).                                      
               5  In this respect, the disclosure at ,e.g., col. 12, lines 29-31, of United States Patent 5,240,853, to         
               Copeland et al., maturing from an application filed March 7, 1989, should be considered in any                   
               further prosecution of the appealed claims before the examiner.  The ‘853 patent was made of                     
               record in the advisory action of December 19, 1994.  We observe that United States Patent                        
               5,482,860, not of record, which matured from an application that is a division of the application                
               from which the ‘853 patent matured, indeed claims an apparatus in which “membrane fragments”                     
               are “immobilized in the reactor chamber” (e.g., claim 1).                                                        
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