Appeal No. 1996-1964
Application No. 07/908,513
The appealed claims read as follows:
49. The compound 2-amino-7-deaza-2',3'-dideoxy-9-beta-D-ribofuran-osyl-
purine-6-one or a triphosphate thereof, in the form of a solution.
50. Reagent for determining a nucleic acid sequence comprising the
compound 2-amino-7-deaza-2',3'-dideoxy-9-beta-D-ribofuranosyl-purine-6-
one or a triphosphate thereof and a nucleotide selected from the group
adenosine, thymidine, cytosine and guanosine.
The references relied on by the examiner are:
Hobbs, Jr. et al. (Hobbs) 5,047,519 Sep. 10, 1991
Tikam C. Jain, et al. (Jain), J. Org. Chem., Volume 38, No. 18, "Reactions of
2-Acyloxyisobutyryl Halides with Nucleosides. III. Reactions of
Tubercidin and Formycin", pgs. 3179-3186 (1973).
Morris J. Robins, et al. (Robins), Can. J. Chem., Volume 55, "Nucleic acid
related compounds. 24. Transformation of tubercidin 2',3'-0-orthoacetate
1,2
into halo, deoxy, epoxide, and unsaturated sugar nucleosides ", pgs. 1251-
1259 (1977).
Saeko Mizusawa, et al. (Mizusawa), Nucleic Acids Research, Volume 14,
No. 3, "Improvement of the dideoxy chain termination method of DNA
sequencing by the use of deoxy-7-deazaguanosine triposphate in place of
dGTP", pgs 1319-1324 (1986).
Claims 49 and 50 stand rejected under 35 U.S.C. § 103 as unpatentable over (1)
the combined disclosures of Hobbs and Mizusawa; (2) the combined disclosures of
Mizusawa and Robins; and (3) the combined disclosures of Mizusawa and Jain.
2
Page: Previous 1 2 3 4 Next
Last modified: November 3, 2007