Appeal No. 1996-2790
Application 08/102,176
Claims 46 and 48 are representative of the subject matter on appeal and read as
follows:
46. A method for decreasing the percutaneous absorption of toxic chemicals
through the skin of a mammal in need of said decreasing which comprises applying to the
stratum corneum of the skin of said mammal an effective amount to decrease the
percutaneous absorption of toxic chemicals of a compound having the formula:
wherein W , W and W are each divalent oxygen, n is 2 and R is a straight chain alkyl1 2 3
radical containing 6 to 20 carbon atoms;
wherein when the skin of said mammal is exposed to said toxic chemicals, the
penetration of said toxic chemicals through the skin is decreased.
48. A method for increasing the stability of lipid bilayers in mammalian skin in order
to decrease passage of bioactive agents through the skin of a mammal in need of said
decreasing, said method comprising the step of applying to the stratum corneum of the
skin of said mammal an amount effective to decrease passage of bioactive agents
through said lipid bilayers of a lipid-bilayer-stability-increasing compound having the
formula:
2
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