Ex parte POHNDORF - Page 11




          Appeal No. 2000-0323                                      Page 11           
          Application No. 08/608,920                                                  


               the dilator are removed and the sheath assembly is                     
               flushed with saline solution through the side arm of the               
               sheath assembly. An appropriate catheter assembly 12, for              
               example, a catheter 22 with a J-tipped guidewire 24 (see               
               FIG. 1) or a straight tip guidewire (not shown), is then               
               advanced through the sheath to the intravascular site or               
               heart chamber under examination. The tip of the guidewire              
               24 is always advanced ahead of the elongated tube portion              
               26 of the catheter 22, to minimize any risk of damage to               
               the walls of the blood vessel. In one embodiment, the                  
               catheter 22 may be advanced through the sheath to the                  
               intravascular site or heart chamber without the use of a               
               guidewire 24. An exemplary catheter for such use is a                  
               conventional multipurpose catheter or a balloon-tipped                 
               catheter.                                                              
                    As depicted in FIGS. 1 and 3, to reach the main                   
               pulmonary arteries 88, 90, the catheter assembly 12 is                 
               first advanced up the femoral vein 80 or 82, with the                  
               connector 28 of the catheter assembly 12 remaining                     
               outside the vein 80 or 82. The catheter assembly 12 is                 
               then connected to the manifold 14 and the catheter                     
               assembly 12 is flushed vigorously. To flush the catheter               
               assembly 12, the control valve 42, 44 or 46 regulating                 
               the flow of saline solution is opened. The required                    
               amount of saline is drawn into the syringe 18. Next, the               
               valve 42, 44 or 46 is closed and the saline may then be                
               injected into the vessel or chamber under treatment.                   
               Medication may also may administered in the same manner.               
                    Under pressure monitoring and/or fluoroscopic                     
               guidance, the catheter assembly 12 is advanced through                 
               the right or left common iliac 96 or 98 and the inferior               
               vena cava 100, into the right atrium 102. The catheter                 
               assembly 12 is then advanced through the tricuspid valve               
               (not shown) into the right ventricle 104, up the                       
               pulmonary trunk 106, and henceforth into the right or                  
               left main pulmonary artery 88 or 90. Once the catheter                 
               assembly 12 reaches the pulmonary trunk 106, or the                    
               cardiac chambers 102, 104, a radiopaque contrast agent                 
               may be injected through the connector 28 of the catheter               







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