Appeal No. 2000-1779 Application No. 08/473,204 absence of appellants’ disclosure a person of ordinary skill in the art would not have known that GluR3A and GluR3B existed. We remind the examiner that “[t]he Patent Office has the initial duty of supplying the factual basis for its rejection. It may not, because it may doubt that the invention is patentable, resort to speculation, unfounded assumptions or hindsight reconstruction to supply deficiencies in its factual basis.” In re Warner, 379 F.2d 1011, 1017, 154 USPQ 173, 178 (CCPA 1967), cert. denied, 389 U.S. 1057 (1968). Here, we agree with the appellants (Brief, pages 8-13) that there is no teaching or suggestion in the applied prior art of the GluR3A receptor having the amino acid sequence of residues 1-866 of SEQ ID NO:2 or the GluR3B receptor having amino acid sequence of residues 1-866 of SEQ ID NO:4 as required by the claim. In re Ochiai, 71 F.3d 1565, 1570, 37 USPQ2d 1127, 1131 (Fed. Cir. 1995); In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598-99 (Fed. Cir. 1988). We also do not find that there was a reasonable expectation that one could have obtained such a receptor sequence required to perform the claimed methods. In re O’Farrell, 858 F.2d 894, 904, 7 USPQ2d 1673, 1681 (Fed. Cir. 1988)(obviousness also requires a “reasonable expectation of success”). 85Page: Previous 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 NextLast modified: November 3, 2007