Appeal No. 2000-1780
Application No. 08/403,663
THE KAINATE CLASS OF GLUTAMATE RECEPTORS
I. The EAA3C & EAA3D Subclass:
Appeal No. 1999-035028
Application No. 08/189,738
Claim 23 is illustrative of the subject matter on appeal and is reproduced
below:
23. A method of assaying a test ligand for binding to a human CNS
receptor, which comprises the steps of incubating the test ligand under
appropriate conditions with a human EAA-3 receptor-producing cell or
with a membrane preparation derived therefrom which contains said
EAA3 receptor and then determining the extent of binding between the
human EAA3 receptor and the test ligand, wherein said cell has been
engineered genetically to produce a kainate-binding human EAA
receptor having incorporated expressibly therein a heterologous DNA
molecule that codes for a human EAA3 receptor selected from the group
consisting of: a human EAA3a receptor having the amino acid sequence
of SEQ ID NO:2, a human EAA3b receptor having the amino acid
sequence of SEQ ID NO:2 with the exception that the amino acid at
position 639 is asparagine instead of aspartate, a human EAA3c
receptor having the amino acid sequence of SEQ ID NO:17, and a
human EAA3d receptor having the amino acid sequence of SEQ ID
NO:18.
28 We recognize appellants’ request (Paper No. 25, received May 5, 1997) for oral
hearing in this appeal. However, in our review of this appeal we find a hearing is not
necessary. 37 CFR § 1.194(c). Accordingly, we make our decision on brief.
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