Appeal No. 2000-1780 Application No. 08/403,663 Where the examiner fails to establish a prima facie case, the rejection is improper and will be overturned. In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988). Having determined that the examiner has not established a prima facie case of obviousness, we find it unnecessary to discuss the Kamboj Declaration executed May 3, 1994, relied on by appellants to rebut any such prima facie case. Accordingly, we reverse the examiner’s rejection of claims 35-38 under 35 U.S.C. § 103 as being unpatentable over Werner in view of Heinemann and Puckett. New Grounds of Rejection under 37 CFR § 1.196(b): Claims 35-38 are rejected under 35 U.S.C. §112, first paragraph, as containing subject matter which was not described in the specification in such a way as to reasonably convey to one skilled in the relevant art that the inventor(s), at the time the application was filed, had possession of the claimed invention. The claims are directed to a method of assaying comprising the steps of incubating a test ligand with a genetically engineered cell that produces “a high affinity kainate-binding” human EAA5 receptor. The specification as originally filed does not describe the human EAA5 receptor subunit as a high affinity kainate binding polypeptide, and the claims as originally filed do not recite the term “high affinity kainate-binding.” Example 3 of the specification shows that the human EAA5a receptor subunit binds kainate, but example 3 does not show that the receptor subunit is a high affinity kainate-binding polypeptide. Thus, the specification does not reasonably convey to the skilled artisan that the inventor, at 36Page: Previous 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 NextLast modified: November 3, 2007