Appeal No. 1996-0449
Application 08/009,423
Ulrich et al. (Ulrich), "Strains Overproducing tRNA for Histidine," Molecular and General
Genetics, Vol. 205, pp. 540-45 (1986).
GROUNDS OF REJECTION
Claims 83 and 86-90 stand rejected under 35 U.S.C. § 103. As evidence of
obviousness, the examiner relies upon Neill, Miller, Garcia, Robinson, Bonekamp and
Ulrich.
Claims 84, 85, 91, and 92 stand rejected under 35 U.S.C. § 103. As evidence of
obviousness, the examiner relies upon Neill, Miller, Garcia, Robinson, Bonekamp, Ulrich,
George, Huala, and Tabor.
We reverse.
BACKGROUND
At pages 3 and 4 of the Specification, applicants describe the invention as relating
to a process for expressing a recombinant gene, which contains codons AGA and/or
AGG, in Escherichia coli after transformation with an expression vector which contains the
recombinant gene wherein the amount of tRNA present in the E.coli host cells is increased
by introducing into the cells an additional DNA sequence coding for such tRNA.
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