Appeal No. 1996-2013
Application No. 07/935,695
DECISION ON APPEAL
This is an appeal under 35 U.S.C. § 134 from the final rejection of claims 1, 3, 4, 8
through 18, 21 and 23 through 25. Claims 19 and 20, the only other claims remaining in
the application, have been withdrawn from consideration by the examiner.
Claims 1, 3 and 21 are representative of the subject matter on appeal and read as
follows:
1. A protein comprising a dimer or multimer of single chain polypeptides wherein
the polypeptides are non-covalently linked and each polypeptide comprises (a) a first
polypeptide comprising an antigen binding portion of a variable domain of an antibody; (b)
a second polypeptide comprising an antigen binding portion of a variable domain of an
antibody and (c) a peptide linker linking the first and second polypeptides (a) and (b) into a
single chain polypeptide having affinity for an antigen wherein the first and second
polypeptide are from antibody CC49.
3. The protein of Claim 1 wherein the first polypeptide is an antigen binding portion
of a light chain variable region of an antibody and the second polypeptide is an antigen
binding portion of a heavy chain variable region of an antibody.
21. A method for producing a dimer or multimer of single chain polypeptides
wherein the polypeptides are non-covalently linked and each polypeptide comprises (a) a
first polypeptide comprising an antigen binding portion of a variable domain of an
antibody; (b) a second polypeptide comprising an antigen binding portion of a variable
domain of an antibody and (c) a peptide linker linking the first and second polypeptides (a)
and (b) into a single chain polypeptide wherein the first and second polypeptide are from
antibody CC49, the method comprising:
(I) providing a genetic sequence coding for a single chain polypeptide;
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