Appeal No. 1996-2419
Application No. 08/282,129
wherein R is hydrogen, C alkyloxy, C alkenyloxy, or C1 1-8 2-8 2-8
alkynyloxy, each can be optionally substituted with hydroxy;
2 x x 4
R is hydroxy, - OC(O)R or -OC(O)OR ; R
and R are5 independently C1-8
alkyl, C alkenyl,2-8 C alkynyl, or -Z-R ;2-8 6
p is zero or one; Z is a direct bond, C1-8
alkylene or C2-8 alkenediyl; R is aryl,6
substituted aryl, C cycloalkyl or
3-8
heteroaryl; and R isx C alkyl optionally,1-8
substituted with one to six same or different halogen atoms,
C cycloalkyl or C alkenyl; or R is a radical of thex
3-8 2-8
formula
wherein D is a bond or C alkyl; and R , R and R are1-8 a b c
independently hydrogen, amino, C alkylamino, di-C1-8 1-
8alkylamino, halogen, C alkyl, or C alkyloxy.1-8 1-8
22. A pharmaceutical composition which comprises an
antitumor effective amount of a compound of claim 1 and a
pharmaceutically acceptable carrier.
-4-
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