Ex parte SLAGA et al. - Page 3




              Appeal No. 1996-2436                                                                                     
              Application 07/887,451                                                                                   



                     On consideration of the record, we shall not sustain this rejection.                              


                                                     Discussion                                                        
                     First, in rejecting claims 1 and 20 through 22 under 35 U.S.C. § 103, the examiner                
              relies on a combination of Amer and “admitted prior art in the specification” (Examiner's                
              Answer, page 3, line 6).   According to the examiner, this passage in applicants'                        
              specification, paragraph bridging pages 7 and 8, constitutes admitted prior art:                         
                                   Several of the antioxidants, vitamins and minerals contained in                     
                            the formulation have been shown to inhibit the induction of cancer at                      
                            several stages in the multistage process.  For example, B-carotene,                        
                            glutathione, cysteine, BHA, BHT, Vitamins A, C and E, as well as                           
                            selenium, inhibit the tumor initiation, promotion and progression                          
                            stages of cancer.  The heretofore unrecognized synergistic effects of                      
                            BHA and Vitamin E, for example, may be related to the observations                         
                            that BHA inhibits tumor promoter-induced polyamine synthesis, and                          
                            that Vitamin E inhibits promoter-induced hyperplasia, thus leading to                      
                            a synergistic effect.  Furthermore, Vitamins A, C and E, selenium,                         
                            BHA, BHT, and propyl gallate inhibit tumor initiation by counteracting                     
                            the covalent binding of carcinogen to DNA and the mutagenic effect                         
                            of carcinogens.                                                                            
              We disagree.  The foregoing passage appears under the heading “SUMMARY OF THE                            
              INVENTION” in the specification, and would not appear to constitute admitted or                          
              acknowledged prior art.  Rather, the foregoing passage constitutes part of the                           





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