Appeal No. 1996-2468
Application 08/091,899
References of record regarding issues of enablement include:
Vane et al. (Vane), “The contribution of prostaglandin production to contractions of the
isolated uterus of the rat,” Br. J. Pharmac., Vol. 48, pp. 629-39 (1973)
Zuckerman et al. (Zuckerman), “Inhibition of Human Premature Labor by Indomethacin,”
The American College of Obstetricians and Gynecologists,
Vol. 44, No. 6, pp. 787-92 (Dec. 1974)
Johnson et al. (Johnson), “Pharmacologic control of uterine contractility: In vitro human and
in vivo monkey studies,” Am. J. Obstet. Gynecol., Vol. 123, No. 4, pp. 364-75 (Oct. 1975)
Demers et al. (Demers), “Placental prostaglandin levels in pre-eclampsia,”
Am. J. Obstet. Gynecol., Vol. 126, No. 1, pp. 137-39 (Sept. 1976)
Valenzuela et al. (Valenzuela), “Effect of pregnancy-induced hypertension upon placental
prostaglandin metabolishm: Decreased prostaglandin F catabolism with normal
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prostaglandin E catabolism,” Am. J. Obstet. Gynecol., pp. 255-56 (Jan. 1980).
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Mäkilä et al. (Mäkilä), “Inreased Thromboxane A ProductionBut Normal Prostacyclin By
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The Placenta In Hypertensive Pregnancies,” Prostaglandins, Vol. 27, No. 1, pp.
87-95 (Jan. 1984)
Walsh, “Preeclampsia: An imbalance in placental prostacyclin and thromboxane
production,” Am. J. Obstet. Gynecol., Vol. 152, No. 3, pp. 335-40 (June 1985)
Murphy et al. (Murphy), “Uterine Insulin-Like Growth Factor-1: Regulation of Expression and
Its Role in Estrogen-Induced Uterine Proliferation,” Endocrine Reviews, Vol. 11, No. 3, pp.
443-53 (1990)
Siler-Khoder et al. (Siler-Khoder), “IGF-I Inhibits Human Placental Prostaglandin F and
Thromboxane B Production,” Department of Obstetrics and Gynecology, University of
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Texas Health Science Center at San Antonio, The 38th Annual Meeting of the Society for
the Study of Reproduction, Abstract #513, p. 179 (1992)
Rall, “Oxytocin, Prostaglandins, Ergot Alkaloids, and other Drugs; Tocolytic Agents,”
The Clinical Use Of Drugs That Inhibit Uterine Motility, Section IX, Chapter 39, pp.
949-53 (1990)
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