Ex parte LADISCH - Page 2




                 Appeal No. 1996-2568                                                                                    
                 Application No. 08/071,304                                                                              




                     1.  A method for suppressing an immune response in an animal which                                  
              comprises administering to the animal an immunosuppressively effective amount of a                         
              ganglioside where said ganglioside is G .                                                                  
                                                       M4                                                                
                     11. A composition for suppressing an immune response in an animal upon                              
              administration to said animal, said composition consisting essentially of:                                 
                     an immunosuppressive concentration of a ganglioside, wherein said                                   
              ganglioside is G ; and                                                                                     
                               M4                                                                                        
                     a physiologically acceptable carrier for said ganglioside.                                          
                     The references relied upon by the examiner are:                                                     
              DeLoach et al. (DeLoach)                  4,327,710                    May   4, 1982                       
              Fabricius et al (Fabricius)               4,388,309                    Jun. 14, 1983                       
              Yates et al. (Yates), Immunological Properties of Gangliosides, American Chemical                          
              Society, Volume 128, pp. 419-33 (1980)                                                                     

                                           GROUNDS OF REJECTION                                                          
                     Claim 1, 7 and 8 are rejected under 35 U.S.C. § 103 as being unpatentable                           
              over Yates in view of Fabricius.                                                                           
                     Claim 9 is rejected under 35 U.S.C. § 103 as being unpatentable over Yates in                       
              view of Fabricius, further in view of DeLoach.                                                             
                     Claim 11 is rejected under 35 U.S.C. § 103 as being unpatentable over Yates.                        
                     Claim 19 is rejected under 35 U.S.C. § 103 as being unpatentable over Yates in                      
              view of Fabricius.                                                                                         


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