Ex parte ROIZMAN et al. - Page 2




               Appeal No. 1996-2639                                                                                                  
               Application No. 08/176,320                                                                                            


               § 103 as obvious over Holland, (2) of claim 8 under 35 U.S.C. § 112, second paragraph, as indefinite                  

               and (3) of claims 7 and 8 under 35 U.S.C. § 112, fourth paragraph, as failing to further the subject                  

               matter of a previous claim, i.e., claim 6 (answer, pages 6-9, section (10) entitled “New grounds of                   

               rejection”).  In the answer, page 16, the examiner states as follows:                                                 

                               In view of the new ground of rejection, appellant is given a period of TWO                            
                       MONTHS from the mailing date of this examiner’s answer within which to file a reply                           
                       to any new ground of rejection.  Such reply may include any amendment or material                             
                       appropriate to the new ground of rejection.  Prosecution otherwise remains closed.                            
                       Failure to respond to the new ground of rejection will result in dismissal of the appeal of                   
                       the claims so rejected.                                                                                       
                                                                                                                                    
               Appellants failed to respond to the new grounds of rejection and, accordingly, the appeal with respect                

               to claims 7, 8, 58 and 63 is dismissed.    Thus, claims 6, 9 through 13, 22, 43 and 66 through 71 are2                                                                             

               the only claims remaining on appeal.                                                                                  

                       Claims 6 and 13 are illustrative of the subject matter on appeal and read as follows:                         

                               6.  An isolated and purified nucleic acid molecule comprising a fragment                              
                       consisting of a sequence encoding a herpes simplex 1 protease, said molecule being                            
                       engineered through the introduction of one or more genetic control elements to control                        
                       the expression of said coding sequence, wherein said control element is one that does                         
                       not normally control expression of the herpes virus protease in the herpes virus genome.                      

                               13.  The nucleic acid molecule of claim 6 comprising a map region essentially as                      
                       set forth in Figure 1, line 5 or line 6.                                                                      


                       2 On March 31, 2000, Gloria Henderson, paralegal with the Board of Patent Appeals and Interferences,          
               spoke on the telephone with Steven L. Highlander, Reg. No. 37,642, counsel for appellants.  In that telephone         
               conversation, counsel indicated that no reply brief was filed in response to the new grounds of rejection and that    
               those claims will probably be dropped.                                                                                
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