Appeal No. 1996-2644 Application 08/232,565 Independent claim 1 is illustrative of the subject matter on appeal and reads as follows: 1. A sealed system for handling, manipulating and formulating materials in an isolated environment, the system comprising: a portable isolation system for performing at least a portion of the handling, manipulating, and formulating, the isolation system having an interior at least partially defined by a plurality of walls, an inlet port for allowing air to flow into the interior, an outlet port for allowing air to flow out of the interior, and a transfer port positioned on one of the walls for transferring items into and out of the isolation system; an autoclave fixedly mounted to a building wall and selectively coupled to the transfer port of the isolation system and having an interior for receiving the items, the interior being accessible through an opening, the building wall having an opening in registry with the opening of the autoclave; a substantially outwardly extending trough of predetermined configuration surrounding one of the transfer port of the isolation system and the opening of the autoclave, the trough having a sealing substance disposed therein; and a substantially outwardly extending blade of predetermined configuration surrounding the other of the transfer port of the isolation system and the opening of the autoclave, the configuration of the blade corresponding to the configuration of the trough, the blade being aligned with and placed within the trough such that the blade sealingly engages the sealing substance within the trough to prevent external matter from passing into the interior of the isolation system and the interior of the autoclave through the transfer port and the opening, the interior of the coupled autoclave being accessible from the interior of the isolation system through the transfer port of the isolation system and the opening of the autoclave. 2Page: Previous 1 2 3 4 5 6 7 NextLast modified: November 3, 2007