Ex parte BIENER - Page 3




                     Appeal No. 1997-0003                                                                                                                                              
                     Application No. 08/342,614                                                                                                                                        
                     therapeutic agent and water.  The examiner primarily relies on the table in col. 2 of the                                                                         
                     patent, which lists the preferred cations and anions as well as their respective                                                                                  
                     concentrations, to demonstrate that Biener would have suggested a method of treating                                                                              
                     acne or seborrheic dermatitis using compositions comprising salt mixtures having anions                                                                           
                     and cations, and a therapeutic agent, within the claimed parameters to one of ordinary skill                                                                      
                     in the art at the time the invention was made.  Answer, pp. 2-3.  We agree, in part.                                                                              
                                                                                          I.                                                                                           
                                Turning first to claims 18 through 20, 31, 32 and 33, we find that they encompass a                                                                    
                     method of treating acne or seborrheic dermatitis which comprises topically applying a                                                                             
                     therapeutic salt composition comprising a mixture of cations (sodium, magnesium,                                                                                  
                     calcium and potassium) and anions (chloride, sulfate, hydrogen carbonate and carbonate),                                                                          
                     a therapeutic agent and a solvent (water).  The salt composition must contain at least 50%                                                                        
                     by weight sodium chloride.  Here, we agree with the examiner that the claimed method of                                                                           
                     treating acne or seborrheic dermatitis would have been obvious to one of ordinary skill in                                                                        
                     the art in view of the teachings of Biener.                                                                                                                       
                                First, the compositions described in the claims comprise ions which are within the                                                                     
                     range taught by the applied prior art.  See, e.g., dependent claim 20.  Under such                                                                                
                     circumstances, our appellate reviewing court has held that when “the difference between                                                                           
                     the claimed invention and the prior art is some range or other variable within the claims ...                                                                     
                     the applicant must show that the particular range is critical, generally by showing that the                                                                      


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