Appeal No. 1997-0093
Application No. 08/157,562
(A) each oligopeptide in said first oligopeptide portion has
(a) a chain that contains the same number of 3 to about 10
amino acid residues, including an oxidized mercaptan-
containing residue that is located at the same position in each
oligopeptide chain and forms part of said disulfide bond, said
oxidized mercaptan-containing residue being the only
mercaptan-containing residue in the chain,
(b) an amino acid residue sequence, in addition to said
oxidized mercaptan-containing residue, that contains one of at
least six predetermined amino acid residues at the same, one
or more predetermined positions of the oligopeptide chain;
and
(B) each oligopeptide in said second oligopeptide mixture portion
bonded to said first oligopeptide portion has
(a) a chain that contains the same number of 3 to about 10
amino acid residues, including an oxidized mercaptan-
containing residue that is located at the same position in each
oligopeptide chain and forms a part of said disulfide bond,
said oxidized mercaptan-containing residue being the only
mercaptan-containing residue resent in the chain, and
said second oligopeptide mixture having equimolar
amounts of said at least six different amino acid residues at
the same one or more other positions of the oligopeptide
chain;
said dimeric oligopeptide mixture set being substantially
free of oligopeptide molecules having no disulfide bond.
2
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