Ex parte BARENHOLZ et al. - Page 3


                  Appeal No.  1997-0661                                                                                       
                  Application No.  08/257,866                                                                                 

                                                       DISCUSSION                                                             
                         In reaching our decision in this appeal, we have given careful consideration                         
                  to the appellants’ specification and claims, and to the respective positions                                
                  articulated by the appellants and the examiner.  We make reference to the                                   
                  examiner’s Answer3 for the examiner’s reasoning in support of the rejection.  We                            
                  further reference appellants’ Brief4, and appellants’ Reply Brief5 for the appellants’                      

                  arguments in favor of patentability.                                                                        
                  THE REJECTION UNDER 35 U.S.C. § 103:                                                                        
                         The initial burden of presenting a prima facie case of obviousness rests on                          
                  the examiner.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444 (Fed.                               
                  Cir. 1992).                                                                                                 
                         The examiner states (Answer, bridging paragraph, pages 3-4) that “Soloviev                           
                  disclose that liposomes made of egg phosphatidylcholine had a relaxing effect on                            
                  the thoracic aortas of spontaneously hypertensive rats.”  The examiner therefore                            
                  concludes that:                                                                                             
                         To administer the liposomes for the treatment of hypertension would                                  
                         have been obvious from the disclosure of Soloviev et al. as the                                      
                         liposomes had a relaxing effect on the aortic smooth muscle.  Thus by                                
                         relaxing blood vessels the pressure in the blood vessel would go                                     
                         down as the diameter of the vessel increased.  Thus a substance                                      
                         known to relax blood vessels would logically be presumed to be useful                                
                         in the treatment of hypertension.                                                                    


                                                                                                                              
                  3 Paper No. 16, mailed April 24, 1996.                                                                      
                  4 Paper No. 15, received March 6, 1996.                                                                     
                  5 Paper No. 17, received June 27, 1996.                                                                     

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