Ex parte ZINKE et al. - Page 3




          Appeal No. 1997-1875                                                        
          Application No. 08/451,378                                                  


               In order for a § 102 rejection to be proper, the                       
          reference must clearly and unequivocally disclose the claimed               
          compound or direct those skilled in the art to the compound                 
          without any need for picking, choosing, and combining various               
          disclosures not directly related to each other by the                       
          teachings of the cited reference.  In re Arkley, 455 F.2d 586,              
          587, 172 USPQ 524, 526 (1972).  Compare In re Petering, 301                 
          F.2d 676, 681, 133 USPQ 275, 279 (1962).  In the case at bar,               
          the only way to derive the here claimed compounds from any of               
          the applied references is via the prohibited exercise of                    
          picking, choosing and combining disclosures within the                      
          respective references.  That is, the appellants' claimed                    
          compounds would be obtained from the applied reference                      
          teachings only by selecting certain choices for numerous                    
          variables within the generic compound formula disclosed in                  
          these references.                                                           
               Under the foregoing circumstances, we cannot regard the                
          applied references as anticipatory of the appealed claims.  It              
          follows that the examiner's § 102 rejection of claims 1                     
          through 13 as being anticipated by the British reference to                 


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