Appeal No. 1997-1965
Application No. 08/466,482
wherein
R is alkyl of 1 to 6 carbon atoms, phenyl or benzyl or substituted phenyl or substituted
benzyl, in which the substituents are halogen, hydroxyl, alkoxy of 1 to 6 carbon atoms
trifluoromethoxy or alkyl of 1 to 6 carbon atoms;
R is hydrogen, halogen, alkoxy of 1 to 6 carbon atoms or alkyl of 1 to 6 carbon
2
atoms;
R is hydrogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, arylalkyl of
1
7 to 12 carbon atoms, or benzyl substituted with halogen, carboxyl, alkoxycarbonyl of 2 to 6
carbon atoms or aryloxycarbonyl of 7 to 12 carbon atoms,
or a pharmaceutically acceptable salt thereof.
20. A method according to Claim 19 wherein said smooth muscle cell
proliferation manifests itself as restenosis following angioplasty.
THE REFERENCES
The prior art references relied on by the examiner are:
Harsányi et al (Harsányi) 4,814,329 Mar. 21, 1989
Raeymaekers et al. (Raeymaekers) 4,859,684 Aug. 22, 1989
Aikawa et al. (Aikawa) 5,387,600 Feb. 7, 1995
Gevaert, “Trimethine dyes containing a 5(6)-benzoylbenzimidazole nucleus,” Chemical
Abstract, Vol. 63: p. 5797b (1965).
Venkataratnam et al. (Venkataratnam), “Studies on formation of 1-aralkyl-2aryl-
6-benzoylbenzimidazoles from 4-benzoyl-o-phenylene diamine and aromatic aldehydes,”
Indian Journal of Chemistry, Vol. 29B, Communication No. 2439, pp. 488-90 (1990).
Beilstein Reference (SO) 5-24, BRN# 811699 (1995).
3
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