Ex parte HERSHENSON - Page 2




                 Appeal No. 1997-2133                                                                                                                
                 Application 08/172,507                                                                                                              



                          Claims 1-7 and 9 are illustrative of the claims on appeal and read as follow:                                              
                          1.       A lyophilized stem cell factor SCF formulation containing histidine.                                              
                          2.       A lyophilized SCF formulation containing glutamic acid.                                                           
                          3.       A lyophilized SCF formulation of claim 1 or 2 wherein said formulation contains                                   
                 sucrose.                                                                                                                            
                          4.       A lyophilized SCF formulation of claims 1 or 2 wherein said formulation contains                                  
                 mannitol.                                                                                                                           

                          5.       A lyophilized SCF formulation containing histidine and glutamic acid.                                             
                          6.       A lyophilized SCF formulation of claim 5 further containing sucrose.                                              
                          7.       A lyophilized SCF formulation of claim 5 further containing mannitol.                                             
                          9.       A method for preparing lyophilized SCF formulation comprised of the steps of:                                     
                          (a) mixing said SCF in a buffer containing an amino acid or amino acids selected from                                      
                 the group consisting of histidine and glutamic acid; and                                                                            
                          (b) lyophilizing said SCF.                                                                                                 

                 The prior art references of record relied upon by the examiner in rejecting the                                                     
                 appealed claims are:                                                                                                                
                 Lee                                         0 314 095                 Oct. 26, 1988                                                 
                 Zsebo et al. (Zsebo)               91/05795                  Sep. 28,1990                                                           
                 (European Patent Application)                                                                                                       
                 Audhya                                      90/12029                  Apr. 9,  1990                                                 
                 Morimoto                                    2,014,009                 Oct. 07,1990                                                  


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