agents have either the requisite molecular weight or charge number. We further
find that the magnetic particles have the requisite particle size 5-50nm. See page
10. However, no surface area is disclosed. Furthermore, the specific examples do
not disclose the requisite combination of molecular weight and charge number.
We find that Groman discloses super paramagnetic oxides as MR imaging agents
which may be surrounded by a polymeric coating. See Abstract. The super
paramagnetic particles have the requisite particle size and surface area. See column
8, lines 1-4. See also column 10, line 67 to column 11, line 4. Stable super
paramagnetic fluids may be prepared by coating the metal oxides with polymeric
substances. See column 16,
lines 1-24. However, the examiner has not shown that these polymeric substances
meet the requirements of the claimed subject matter.
We further find that Pilgrimm discloses a magnetic liquid composition containing
aqueous dispersions of stabilized super paramagnetic particles chemically bonded to
phosphate, phosphonate or carboxylate groups. Both particle size and surface area
are disclosed at column 3, lines 8-10. The stabilizer substances to which the
magnetic particles are bonded are taught at column 3, lines 33-38. For aqueous,
magnetic liquid compositions the stabilizers appear to be taught at column 3, lines 60
to column 4, line 30 and include polymethacrylic or polyacrylic acid. However, no
molecular weight for the polymethacrylic acid or polyacrylic acid is disclosed.
Based upon the above findings and analysis, we determine that none of the
references taken alone or together suggest or teach all of the claimed
compositional limitations, let alone the derived relaxivity limitations of the claimed
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