Ex parte BECKNER et al. - Page 4




                   Appeal No. 1997-2372                                                                                                                             
                   Application 08/083,945                                                                                                                           



                                      prosecution history, is a matter of law and will normally control                                                             
                                      the remainder of the decisional process.  [Footnote omitted.]                                                                 
                   To that end, we also note that during ex parte prosecution, claims are to be given their                                                         
                   broadest reasonable interpretation consistent with the description of the invention in the                                                       
                   specification.  In re Zletz, 893 F.2d 319, 321, 13 USPQ2d 1320, 1322 (Fed. Cir. 1989).                                                           
                   The doctrine of claim differentiation creates a presumption that each claim in a patent has                                                      
                   a different scope.  Comark Communications, Inc. v. Harris Corp., 156 F.3d 1182, 1187, 48                                                         
                   USPQ2d 1001, 1005 (Fed. Cir. 1998). "There is presumed to be a difference in meaning                                                             
                   and scope when different words or phrases are used in separate claims. To the extent that                                                        
                   the absence of such difference in meaning and scope would make a claim superfluous, the                                                          
                   doctrine of claim differentiation states the presumption that the difference between claims                                                      
                   is significant."  Id. at 1005.  For purposes of this appeal, we interpret claim 6, directed to                                                   
                   “A substantially pure polypeptide comprising an amino acid sequence showing at least                                                             
                   90% sequence identity to SEQ ID NO. 7, or a fragment thereof,” as broadly  encompassing                                                          
                                                                                                                                   1                                
                   both peptides which bind to heparin and peptides which do not bind to heparin.   This                                                            
                   interpretation is supported by the doctrine of claim differentiation, as claim 37, dependent                                                     
                   upon claim 6, is directed to “The substantially pure peptide of claim 6, that is capable of                                                      
                   binding to heparin.”  Therefore, we interpret claim 37 as directed to a subset of the                                                            

                            1SEQ ID NO:7 is an amino acid sequence corresponding to AAMP-1 polypeptide                                                              
                   encoded by an open reading frame in DNA of AAMP-1.   Specification pages 15 and 25.                                                              
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