Appeal No. 1997-2750
Application 08/191,734
THE INVENTION
The present invention relates to topical pharmaceutical compositions having
enhanced penetration through the skin. These compositions comprise a safe and effective
amount of a “pharmaceutical active” or drug and from about 0.1% to about 10% of a high
molecular weight crosslinked cationic polymer. The crosslinked polymer is defined by way
of formula in the appealed claims.
Claims 1, 4, 5, and 23, which are illustrative of the subject matter on appeal, read
as follows:
1. A topical pharmaceutical composition having enhanced penetration through the
skin comprising:
(a) a safe and effective amount of a pharmaceutical active; and
(b) from about 0.1% to about 10.0% of a high molecular weight crosslinked cationic
polymer of the formula: (A)(B) (C) wherein (A) is a dialkylaminoalkyl acrylate monomer or
l m n
its quaternary ammonium or acid addition salt, (B) is a dialkylaminoalkyl methacrylate
monomer or its quaternary ammonium or acid addition salt, (C) is acrylamide, l is an
integer of 0 or greater, m is an integer of 1 or greater, and n is an integer of 0 or greater,
wherein said polymer contains a crosslinking agent.
4. The composition of Claim 3 wherein said pharmaceutical active is selected from
the group consisting of anti-acne drugs, non-steroidal anti-inflammatory drugs, steroidal
anti-inflammatory drugs, sunless tanning agents, sunscreen agents, wound healing agents,
skin bleaching or lightening agents, antihistaminic drugs, antitussive drugs, antipruritic
drugs, anticholinergic drugs, anti-emetic and antinauseant drugs,
2
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