Appeal No. 1997-3010
Application 08/042,461
Claim 47 is illustrative and read as follows:
47. A method for the treatment of vascular disorders, comprising:
exposing an external surface of an artery or vein;
applying a polymer matrix, which is permeable to an agent for the
treatment of a vascular disorder and is impregnated with said agent, directly
to said external surface; and
covering said polymer matrix with a barrier adapted to restrict the
release of said agent into tissue adjacent to said artery or vein, so that said
agent diffuses from said polymer directly to said external surface of said
artery or vein, thereby producing a localized effect on said artery or vein
without systemic effect.
The references relied on by the examiner are:
Urquhart 3,797,485 Mar. 19, 1974
Moskowitz et al. (Moskowitz), “Controlled release of horseradish peroxidase from
polymers: a method to improve histochemical localization and sensitivity,” Brain
Research, Vol. 212, pp. 460-65 (1981).
Castellot et al. (Castellot), “Structural Determinants of the Capacity of Heparin to
Inhibit the Proliferation of Vascular Smooth Muscle Cells,” Journal of Cellular
Physiology, Vol. 120, pp. 315-20 (1984).
1. Claims 28 through 31, 34, 38, 39, 47, 49, and 52 stand rejected under
35 U.S.C. 103(a). As evidence of obviousness, the examiner relies on Moskowitz.
2. Claims 31 and 34 stand rejected under 35 U.S.C. 103(a). As evidence of
obviousness, the examiner relies on Moskowitz and Castellot.
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