Appeal No. 1997-3537
Application No. 08/395,867
1. An article of manufacture for use in altering the appearance to the
immune system of an infant of protein sections of bovine serum albumin,
said article of manufacture comprising
(a) a sealed container;
(b) a nutritionally balanced milk formulation in said sealed
container, said milk formulation including bovine serum
albumin and including an active protease enzyme in a
concentration of 0.025 to 100 milligrams of said enzyme per
liter of said milk formulation, said protease enzyme in said
container cleaving protein-to-protein bonds to alter the
structure of said bovine serum albumin.
2. A dietary enzymatic process for enabling the immune system of an
infant to distinguish between the ABBOS amino acid section of bovine
serum albumin and the p69 amino acid section of insulin-producing beta
cells, comprising the steps of
(a) preparing an infant milk formula, said infant milk formula being
prepared by
(i) sterilizing a milk formulation including bovine serum
albumin;
(ii) adding a sterilized protease enzyme to said milk
formulation in a concentration of 0.025 to 100
milligrams of said enzyme per liter of said milk
formulation;
(b) packaging said infant milk formula prepared in step (a) in a
sealed container such that while said milk formula is in said
container, said protease enzyme cleaves peptide bonds of
said bovine serum albumin to alter the ABBOS amino acid
section of the bovine serum albumin such that anti-ABBOS
antibodies produced by an infant ingesting said infant milk
formula will not attack the p69 amino acid section of insulin-
producing beta cells in the infant; and,
(c) feeding the infant by opening said container and administering
said infant milk formula to the digestive tract of the infant such
that the infant's immune system is exposed to the altered
ABBOS amino acid section of the bovine serum albumin.
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