Appeal no. 1997-3953 Application 08/392,615 claimed composition that would distinguish it from the prior art composition (which is clearly capable of supporting the growth of malolactic bacteria). In re Pearson, 494 F.2d 1399, 1403, 181 USPQ 641, 644 (CCPA 1974). Similarly, the examiner’s rationale for modifying Henick-Kling’s medium relies on one of ordinary skill in the art having some reason to convert the prior art medium to a “starter medium,” but no reason is given. Moreover, there is uncontroverted evidence of record that the ratio of fructose to glucose does not increase during the ripening of grapes. See the declaration of Dr. Henick-Kling, submitted December 14, 1995. In our view, the only difference between Henick-Kling’s MRSM and the claimed medium is the ratio of glucose to fructose, and/or the overall concentration of glucose plus fructose; and the dispositive issue is simply whether there is any reason, stemming from the prior art, to modify the carbohydrate content of Henick-Kling’s MRSM in the manner required by the present claims. Turning to the Examiner’s Answer (pages 4 and 5), under the heading “Response to Argument,” we find the following statement from the examiner: It has been clearly established in the prosecution of this case that the prior art discloses that the various proportions and amounts of the ingredients used in the claimed composition, i.e. fructose/glucose and malic acid, are result effective variables which be [sic] routinely optimized by one of ordinary skill in the art in practicing the invention disclosed by that reference . . . [i]t is well within the purview of the skilled artisan to vary fermentation conditions via routine experimentation in order to optimize microbial growth or production. 6Page: Previous 1 2 3 4 5 6 7 8 9 NextLast modified: November 3, 2007