Appeal No. 1999-1181
Application 08/480,332
DECISION ON APPEAL
This is an appeal under 35 U.S.C. § 134 from the final rejection of claims 2 through
4 and 6 through 9, all the claims pending in the application.
Claim 8 is illustrative of the subject matter on appeal and reads as follows:
8. A liposome composition for use in treating a condition mediated by binding
of one binding member, which is a pathogen or cell in the bloodstream, to a second
binding member, which is a target cell or cell matrix, comprising
liposomes having an outer surface layer of polyethylene glycol chains, each
chain having a free distal end, and
covalently attached to a portion of said distal chain ends, a polypeptide or
polysaccharide effector molecule which (i) interferes with specific binding between said
first and second binding members, and (ii) is rapidly removed by renal clearance from the
bloodstream when administered in free form,
wherein binding of the liposomes to one of said first or second binding
members is effective to inhibit binding between said first and second binding members.
The references relied upon by the examiner are:
Woodle et al. (Woodle) 5,013,556 May 7, 1991
Eur. Pat. App. (Handley) 0 428 486 May 22, 1991
Kawasaki et al. (Kawasaki), “Amino Acids and Peptides, XIV. Laminin Related Peptides
and their Inhibitory Effect on Experimental Metastasis Formation”, Biochem. Biophys.
Res. Comm., vol.174, no. 3, (Feb. 14, 1991), pp. 1159-1162.
Klibanov et al. (Klibanov), “Long-Circulating Liposomes: Development and Perspectives”,
Journal of Liposomes Research, vol. 2, no. 3, (1992), pp. 321-334.
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