Ex parte HAVENS et al. - Page 6



                Appeal No. 2000-0091                                                                          
                Application No. 08/732,254                                                                    

                applicant.”  In re Rijckaert, 9 F.3d 1531, 1532, 28 USPQ2d 1955, 1956 (Fed. Cir.              
                1993).                                                                                        
                      The examiner’s obviousness rejection seems to suffer the same infirmity                 
                as her anticipation rejection, namely, that it is directed to delavirdine mesylate            
                per se, rather than to the specific S and T crystal forms of delavirdine mesylate             
                that are the subject of the claims on appeal.  The examiner has provided no                   
                evidence or convincing reasoning why the prior art disclosure of delavirdine                  
                mesylate in an undefined state would have suggested the specific S and T                      
                crystal forms that are the subject of the instant claims.                                     
                      Nor has the examiner established that Palmer would have enabled those                   
                skilled in the art to make the claimed S and T crystal forms of delavirdine                   
                mesylate.  Appellants’ specification discloses specific conditions for                        
                recrystallizing delavirdine mesylate that produce the S and T crystal forms.  See             
                pages 2-4 and Examples 1-8.  Palmer does not disclose or suggest even the                     
                existence of the S and T crystal forms of delavirdine mesylate, let alone how to              
                make them.  As stated in In re Hoeksema:                                                      
                      [I]f the prior art of record fails to disclose or render obvious a                      
                      method for making a claimed compound, at the time the invention                         
                      was made, it may not be legally concluded that the compound itself                      
                      is in the possession of the public.  In this context, we say that the                   
                      absence of a known or obvious process for making the claimed                            
                      compounds overcomes a presumption that the compounds are                                
                      obvious, based on close relationships between their structures and                      
                      those of prior art compounds.                                                           
                399 F.2d 269, 274, 158 USPQ 596, 601 (CCPA 1968) (footnote omitted).                          



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