LAGRANGE et al v. KONRAD et al - Page 61




                 Patent Interference No. 103,548                                                                                                 
                 Goldemberg) and propylene glycol (i.e., Goldemberg et al.) are on the list of possible                                          
                 solvents provided for by Lagrange's reissue claim 31.                                                                           
                         The Goldemberg disclosures suggest that a hair dye formulator would have                                                
                 considered employing a water/solvent medium containing for example ethanol or                                                   
                 propylene glycol, among other solvents, for the purpose of increasing dye uptake or as                                          
                 a standard medium for studying the effect of additives on dyes. The disclosures                                                 
                 encompass oxidation dyes, which would appear to include the indolines that are set                                              
                 forth in either of Lagrange patent claim 5 or Konrad claim 4. There is a reasonable                                             
                 expectation that when such an indoline is in a water/solvent medium containing ethanol                                          
                 or propylene glycol, it would, like other dyes, show for example an increase in dye                                             
                 uptake. For this reason, it would have been obvious to one of ordinary skill in the art to                                      
                 select the particular water/solvent mixtures set forth in Lagrange reissue claim 31 from                                        
                 the broad genus of mediums encompassed by the presumed prior art, i.e., Lagrange                                                
                 patent claim 5 and Konrad claim 4, in view of the Goldemberg disclosures.                                                       
                         Lagrange (LOB 35-37) disputes the relevance of the Goldemberg disclosures on                                            
                 the grounds that it is directed to any dye; that is, it does not specifically disclose indoles                                  
                 or indolines, and does not provide the necessary incentive to substitute Konrad’s carrier                                       
                 with a solvent.                                                                                                                 
                         The first argument is unpersuasive. The Goldemberg and Goldemberg et al                                                 
                 disclosures are very clear in stating that they are describing the effect of formulation                                        
                 factors/conditions and additives as they relate to any dye or any oxidation dye,                                                
                 respectively. To one of ordinary skill reading these references, the indication is that the                                     


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