Ex parte BODDE et al. - Page 2


              Appeal No. 1995-1303                                                                                       
              Application 08/004,603                                                                                     

                     Claims 1 through 7 stand rejected under 35 U.S.C. § 103(a).  As evidence of                         
              obviousness, the examiner relies upon Minaskanian, Rajadhyaksha and Francoeur.  We                         
              reverse.                                                                                                   
                                                      Discussion                                                         
                     We initially note that the Examiner’s Answer is difficult to review since the                       
              examiner refers us to Paper No. 8 for a statement of the rejection.  However, Paper No.                    
              8 indicates that the claims are rejected for “the reasons of record.”  The only statement                  
              of a rejection we find in the case is the first office action where the examiner states:                   
                            The instant compound, composition and use is generically taught by                           
                     Minaskanian et al. in column 2, line 30.  The corresponding saturated compound                      
                     is taught by Rajadhyaksha in column 2, line 5.  Francoeur et al. teaches the use                    
                     of compositions containing the compounds of the two primary references along                        
                     with various unsaturated acid[s], including oleic acid, as epithelial membrane                      
                     permeability enhancing agents.  One skilled in the art would expect a compound                      
                     which shows the structure of oleic acid and the structure of the compounds of the                   
                     two primary references to possess similar epithelial membrane permeability                          
                     enhancing properties.  The substitution of the oleic chain from oleic acid for the                  
                     corresponding saturated c18 alkyl group one [sic, on] the azocycloheptan-2-one of                   
                     the primary references would be expected to produce a compound with the                             
                     instant properties and use given the teaching of Rajadhyaksha.  The combination                     
                     renders the instant claims prima facie obvious absent a showing of unexpected                       
                     properties.                                                                                         
                     The examiner’s position presupposes that it would have been obvious to focus                        
              on the C18 derivatives of Rajadhyaksha or Minaskanian.  However, that supposition is                       
              open to question.  The Examiner’s Answer was mailed September 9, 1994.  The court                          
              issued its opinion in In re Baird, 16 F.3d 380, 29 USPQ2d 1550 (Fed. Cir. 1994) in                         
              January 1994.  Therein, the court stated “the fact that a claimed compound may be                          
              encompassed by a disclosed generic formula does not by itself render that compound                         
              obvious. In re Jones, 958 F.2d 347, 350, 21 USPQ2d 1941, 1943 (Fed. Cir. 1992).”                           
              Baird, 16 F.3d at 382, 29 USPQ2d at 1552.   In light of this precedent, which issued                       

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