Ex parte ROTH et al. - Page 9


                  Appeal No.  1996-2756                                                                                        
                  Application No.  07/987,235                                                                                  
                  than the closest prior art.”  In response, the examiner argues (Answer, bridging                             
                  paragraph, pages 9-10) that “[i]t is noted that the declaration is directed to support                       
                  claims to a composition, not claims to a method.  The antisense oligonucleotides                             
                  used in the declaration would have been obvious to the ordinary artisan at the time                          
                  of the instant invention for the reasons given above….”  In our opinion, the examiner                        
                  has not adequately addressed appellants’ declaration.  We remind the examiner                                
                  that a conclusion of prima facie obviousness does not end a patentability                                    
                  determination under 35 U.S.C. § 103.  As set forth in In re Hedges, 783 F.2d 1038,                           
                  1039, 228 USPQ 685, 686 (Fed. Cir. 1986):                                                                    
                          If a prima facie case is made in the first instance, and if the applicant                            
                          comes forward with reasonable rebuttal, whether buttressed by                                        
                          experiment, prior art references, or argument, the entire merits of the                              
                          matter are to be reweighed.  In re Piasecki, 745 F.2d 1468, 1472,                                    
                          223 USPQ 785, 788 (Fed. Cir. 1984).                                                                  
                          To the extent that the examiner argues that the declaration is not relevant to                       
                  the composition, we note that “[f]rom the standpoint of patent law, a compound and                           
                  all of its properties are inseparable; they are one and the same.”  In re Papesch,                           
                  315 F.2d 381, 391, 137 USPQ 43, 51 (CCPA 1963).  In this regard, the examiner                                
                  should have reevaluated her prima facie case after full consideration of the                                 
                  declaration, along with entirety of the facts and arguments of record.  Even had a                           
                  prima facie case of obviousness had been made in the first instance, in view of the                          
                  evidence of record, such a prima facie case of obviousness of record would not be                            
                  sustainable.                                                                                                 
                          Accordingly, we reverse the rejection of claims 12, 13, 16, 25 and 30-32                             
                  under 35 U.S.C. § 103 as being unpatentable over Weinberg in view of Izant.                                  

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