Ex parte REYES et al. - Page 2






              Appeal No. 1997-0473                                                                                       
              Application No. 07/870,985                                                                                 
                     The references relied on by the examiner are listed below:                                          
              Webster’s New World Dictionary of American English, Third College Edition,                                 
              V. Neufeldt and D.B. Guralink eds., Simon & Schuster, Inc., New York, NY, p. 691                           
              (1988)                                                                                                     
              Cohen, “Immunization,” Basic & Clinical Immunology, Stites et al., eds., Lange Medical                     
              Publications, Los Altos, Ca., 4th edition, Chp. 39, pp. 703-706 (1982)                                     
              Bradley et al. (Bradley), “Enterically transmitted non-A, non-B hepatitis: Serial passage of               
              disease in cynomolgus macaques and tamarins and recovery of disease-associated 27-                         
              to 34-nm viruslike particles,” Proc. Natl. Acad. Sci., Vol. 84, pp. 6277-3281 (1987)                       
                                                Grounds of Rejection                                                     

                     Claims 15 - 18 and 20 stand rejected under 35 U.S.C. § 112, first paragraph, as                     
              being based on a non-enabling disclosure.  As evidence the examiner relies on Webster’s                    
              New World Dictionary of American English, Third College Ed. and Cohen                                      
                     Claims 15 - 18 and 20 stand rejected under 35 U.S.C. § 103.  As evidence of                         
              obviousness, the examiner relies on Cohen and Bradley.                                                     
                     We reverse the rejection under 35 U.S.C. § 103 and vacate the rejection under 35                    
              U.S.C. § 112, first paragraph, for the reasons set forth herein.                                           
                                                     Background                                                          

                     Applicants describe their invention, as presently claimed, at pages 4-5 of the                      
              Specification as being directed to a method of preventing or treating a hepatitis E virus                  
              (HEV) infection in an individual by administering, thereto, an antibody vaccine composition                
              capable of neutralizing HEV infection as evidenced by the ability of the composition to                    

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