Ex parte THOMAS - Page 7




              Appeal No. 1997-2087                                                                                            
              Application No. 08/203,837                                                                                      


              remove cysts (Abstract).  This combination is reported to kill cysts of Acanthamoeba                            
              castellani more effectively.                                                                                    
                      The examiner states that it would have been obvious to combine these references                         
              and arrive at appellant's invention because                                                                     
                             the practitioner would be aware that the lysozyme 1) would                                       
                             potentiate the activity of the hydrogen peroxide in destroying                                   
                             Acanthamoeba cysts per the disclosure of Izumi et al. and 2)                                     
                             when lysozyme was included in the composition, [sic, it] would                                   
                             need to be separated from the cleaning enzyme component                                          
                             until after it has had its disinfecting effect because the cleaning                              
                             enzyme component would inactivate the lysozyme (Examiner's                                       
                             Answer, paragraph bridging pages 6 and 7).                                                       
              Upon consideration of the entire record before us, we cannot sustain the examiner's                             
              rejection.                                                                                                      
                                                       DISCUSSION                                                             

                      Patentability of a claim under 35 U.S.C. § 103 must be premised upon considering                        
              the subject matter of a claim "as a whole."  As recently stated in Pro-Mold                                     
              & Tool Co. v. Great Lakes Plastics, Inc., 75 F.3d 1568, 1573, 37 USPQ2d 1626, 1629                              
              (Fed. Cir. 1996) (citation omitted): "It is well-established that before a conclusion of                        
              obviousness may be made based on a combination of references, there must have been a                            
              reason, suggestion, or motivation to lead an inventor to combine those references."                             
                      The nature of the problem which persisted in the art, and the inventor's solution, are                  
              factors to be considered in determining whether the invention would have been obvious to                        
              a person of ordinary skill in that art.  Fromson v. Advance Offset Plate, Inc., 755 F.2d 1549,                  


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