Appeal No. 1997-2743
Application No. 08/442,252
Claims 1, 7, 8 and 17 are representative of the subject matter on appeal and read
as follows:
1. A radiopharmaceutical kit comprising:
at least one ligand capable of bonding to a radioisotope during
radiopharmaceutical solution formulation, wherein said ligand is selected from the group
consisting of phosphines, arsines, thiols, thioethers, and isonitriles; and
a cyclic oligosaccharide as a stabilizing compound in an amount suitable to inhibit
oxidation and/or volatilization of the ligand.
7. A radiopharmaceutical kit according to claim 1, wherein said cyclic
oligosaccharide is a modified or unmodified cyclodextrin.
8. A radiopharmaceutical kit according to claim 7, wherein said modified or
unmodified cyclodextrin is selected from the group consisting of "-cyclodextrin, $-
cyclodextrin, and (-cyclodextrin.
17. A radiopharmaceutical kit according to claim 1, wherein said radioisotope is
technetium or rhenium.
The references relied on by the examiner are:
Feld et al. (Feld) 4,714,605 Dec. 22, 1987
Pitha 4,727,064 Feb. 23, 1988
Deutsch 5,002,754 Mar. 26, 1991
Woulfe et al. (Woulfe) 5,112,595 May 12, 1992
The claims stand rejected under 35 U.S.C. § 103 as follows:
I. Claims 1, 3 through 8 and 15 through 18 as unpatentable over Feld, Deutsch and
Woulfe.
II. Claims 9 through 12 as unpatentable over Feld, Deutsch, Woulfe and Pitha.
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