Ex parte ABE et al. - Page 4


              Appeal No. 1997-4226                                                                                           
              Application 08/501,152                                                                                         

              before us there must be adequate support in the prior art for the ester/thioester change in structure, in      
              order to complete the PTO’s prima facie case and shift the burden of going forward to the applicant.”).        
                      To the extent that a prima facie case of obviousness had been made out by the examiner over            
              Schnur, the factual arguments presented by appellants in rebuttal shifted the burden back to the               
              examiner to again establish the factual underpinning of a prima facie case under § 103(a) in order to          
              maintain each of the grounds of rejection.  See, e.g., Oetiker, supra.  This the examiner has not done.        
                      The examiner’s decision is reversed.                                                                   
                                                          Reversed                                                           









                                    CHARLES F. WARREN                           )                                            
                                    Administrative Patent Judge                 )                                            
                                                                                )                                            
                                                                                )                                            
                                                                                )                                            
                                    PETER F. KRATZ                              )   BOARD OF PATENT                          
                                    Administrative Patent Judge                 )        APPEALS AND                         
                                                                                )      INTERFERENCES                         
                                                                                )                                            
                                                                                )                                            
                                    JEFFREY T. SMITH                            )                                            
                                    Administrative Patent Judge                 )                                            










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