Ex Parte PORTOGHESE et al - Page 4


             Appeal No. 1998-1489                                                                                     
             Application No. 08/449,224                                                                               
             decision and accompanying opinion in the latter appeal, mailed February 28, 2001, the                    
             board reversed the examiner’s rejections on non-prior art grounds.  Having carefully                     
             considered the similar issues in this appeal, we find, again, that the examiner (1) does                 
             not provide sufficient analysis of the specification or how persons skilled in the art would             
             read the instant claims in light of the specification; (2) does not provide adequate                     
             reasons to doubt the objective truth of statements made in appellants’ specification; and                
             (3) does not establish a prima facie case of indefiniteness of any appealed claim.                       
                    For reasons given in Appeal No. 1997-2204, we reverse the examiner’s                              
             rejections under 35 U.S.C. § 112, first and second paragraphs, to the extent that they                   
             involve the same issues previously decided.                                                              


             II.    Remaining issue under 35 U.S.C. § 112, first paragraph                                            
                    The remaining issue, which merits separate discussion, is whether the examiner                    
             erred in rejecting claims 1 through 9 and 22 under 35 U.S.C. § 112, first paragraph,                     
             based on the unavailability of requisite starting materials for preparing some of the                    
             compounds embraced by these claims (Examiner’s Answer, pages 4 through 6).                               
                    Specifically, claims 1 through 9 and 22 stand rejected under 35 U.S.C. § 112,                     
             first paragraph, as based on a non-enabling disclosure because “competent sources of                     
             starting materials for R4 as carbonyl and X as O or NY are lacking and are required for                  
             enablement” (Examiner’s Answer, Page 4, section (11) ).                                                  


                    The examiner argues that                                                                          
                           Dappen ‘417 patented the intermediate X as NY acids used for the                           
                    claimed amides subsequently to instant parent filing date, raising a prima facie                  


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