Appeal No. 1999-0197
Application 08/054,970
34. A method of inhibiting signal transduction in tumor necrosis factor receptors
(TNF-Rs), comprising:
identifying a molecule which binds to the portion of TNF-R which includes Ser197 or
the amino acids 405 to 415 of human p55-TNF-R (SEQ ID NO:2) or the corresponding
amino acids of the human p75-TNF-R, and thereby causes the signal transduction of said
receptor to be inhibited; and
bringing said molecule into contact with said portion of TNF-R.
37. A method for identifying molecules which interact with TNF-R to modulate
signal transduction by the TNF-R, comprising:
a) preparing a target peptide which includes amino acids 405-415 of human p55-
TNF-R (SEQ ID NO:2) or the corresponding amino acids of human -75-TNF-R;
b) screening peptide libraries and/or broth of biological matter with said target
peptide and identifying any molecules which bind to said target peptide; and
c) screening any molecules identified in step b) for their ability to modulate signal
transduction of TNF-R and identifying any molecule which tests positive for such signal
transduction modulation.
42. A method of inhibiting signal transduction in tumor necrosis factor receptors
(TNS-Rs), comprising:
identifying a molecule which reacts with TNF-R to modulate signal transduction by
the TNF-R, by means of a process in accordance with claim 37; and
bringing said molecule into contact with the portion of TNF-R which includes amino
acids of human p75-TNF-R.
43. A method in accordance with claim 37, for identifying a molecule which
interacts with TNF-R to inhibit signal transduction by the TNF-R, wherein said step c)
comprises screening any molecules identified in step b) for their ability to inhibit signal
transduction of TNF-R and identifying any molecule which tests positive for such signal
transduction inhibition.
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