Ex parte KHAN et al. - Page 9




          Appeal No. 1999-0529                                                        
          Application 08/588,800                                                      


          skill in the art.  Uniroyal, Inc. v. Rudkin-Wiley Corp., 837                
          F.2d 1044, 1051, 5 USPQ2d 1434, 1438 (Fed. Cir.), cert.                     
          denied, 488 U.S. 825 (1988); Ashland Oil, Inc. v. Delta Resins              
          & Refractories, Inc., 776 F.2d 281, 293, 227 USPQ 657, 664                  
          (Fed. Cir. 1985), cert. denied, 475 U.S. 1017 (1986); ACS                   
          Hosp. Sys., Inc. v. Montefiore Hosp., 732 F.2d 1572, 1577, 221              
          USPQ 929, 933 (Fed. Cir. 1984).  These showings by the                      
          examiner are an essential part of complying with the burden of              
          presenting a prima facie case of obviousness.  Note In re                   
          Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444 (Fed. Cir.               
          1992).  If that burden is met, the burden then shifts to the                
          applicant to overcome the prima facie case with argument                    
          and/or evidence.  Obviousness is then determined on the basis               
          of the evidence as a whole and the relative persuasiveness of               
          the arguments.  See Id.; In re Hedges, 783 F.2d 1038, 1039,                 
          228 USPQ 685, 686 (Fed. Cir. 1986); In re Piasecki, 745 F.2d                
          1468, 1472, 223 USPQ 785, 788 (Fed. Cir. 1984); and In re                   
          Rinehart, 531 F.2d 1048, 1052, 189 USPQ 143, 147 (CCPA 1976).               
          Only those arguments actually made by appellants have been                  
          considered in this                                                          


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