Appeal No. 1999-0959
Application No. 08/415,166
presence of at least one compound selected from the group
consisting of an amino acid, a saccharide and a sugar-alcohol and
also in the presence of calcium ions and a chelating agent, wherein
the concentration of calcium ions is from 1 to about 30 mmol/l and
the concentration of the chelating agent is from 1 to about 7 mmol/l.
5. The process as claimed in claim 8, wherein the solution is heated in
the presence of 0.2-2 units/ml of antithrombin III, 2-20 USP units/ml
of heparin, 25 to 30 mmol/l of calcium ions, 1 to 7 mmol/l of EDTA,
1-3 mol/l of at least one amino acid selected from the group
consisting of glycine, alpha -alanine, beta -alanine, lysine, leucine,
valine, asparagine, serine, hydroxyproline, proline and glutamine or
one substance selected from the group consisting of alpha-
aminobutyric acid, beta-aminobutyric acid and gamma-aminobutyric
acid, and 20 to 60 g/100 g of a solution of a mono-saccharide,
oligo-saccharide or sugar-alcohol.
The examiner relies on the following references:
Schwinn et al. (Schwinn ‘187) 4,404,187 Sept. 13, 1983
Schwinn et al. (Schwinn ‘603) 4,405,603 Sept. 20, 1983
Claims 3, 5-8, and 11-22 stand rejected under 35 U.S.C. § 112, first
paragraph, as unsupported by an adequate written description.
Claims 3, 5-8, and 11-22 also stand rejected under 35 U.S.C. § 103 as
obvious over Schwinn ‘187 and Schwinn ‘603.
We reverse both of the rejections.
Background
Appellants’ specification discloses a method for inactivating viruses in a
preparation of blood coagulation factors. The method involves heating the
preparation in the presence of an amino acid, a saccharide, and/or a sugar
alcohol, in the presence of calcium ions and a chelating agent. See page 4.
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