Appeal No. 1999-2231
Application No. 08/278,774
specific proteolytic agent recognition site, wherein said second non-
natural site-specific proteolytic agent recognition site is located
between said collagen chain and said second propeptide.
The references relied upon by the examiner are:
Olsen et al. (Olsen), “Purification and Characterization of a Peptde from the
Carboxy-Terminal Region of Chick Tendon Procollagen Type I,” Biochemistry,
Vol. 16, No. 13, pp. 3030-3036 (1977)
Prockop et al. (Prockop), “The Biosynthesis of Collagen and its Disorders,” New
England Journal of Medicine, Vol. 301, No. 1, pp. 13-23 (1979)
Chu et al. (Chu), “Human proI1(I) collagen gene structure reveals evolutionary
conservation of a pattern of introns and exons,” Nature, Vol. 310, pp. 337-340
(1984)
Carter, “Site-Specific Proteolysis of Fusion Proteins,” Protein Purification: From
Molecular Mechanisms to Large-Scale Processes, Vol. 47, Chp. 13, pp. 181-193
(American Chemical Society 1990)
GROUND OF REJECTION1
Claims 1-3, 6-9, 14-16 and 18 stand rejected under 35 U.S.C. § 103 as
being unpatentable over Chu, Prockop and Olsen in view of Carter.
We affirm the rejection of claims 1-3, 8, 9, 14-16 and 18. We reverse the
rejection of claims 6 and 7.
DISCUSSION
In reaching our decision in this appeal, we considered appellants’
specification and claims, in addition to the respective positions articulated by the
appellants and the examiner. We make reference to the examiner’s Answer2,
and the for the examiner’s reasoning in support of the rejections. We further
1 We note the examiner withdrew the Final rejection of claim 14 under 35 U.S.C.
§ 112, first and second paragraph. Answer, page 3.
2 Paper No. 29, mailed June 19, 1998. We note the Answer incorrectly notes
that it is Paper No. 27. Paper No. 27, mailed May 19, 1998 represents a
Notification of non-compliance with the requirements of 37 CFR § 1.192(c).
2
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