compounds formed in examples 2, 3 and 4 possess an E group that is N-R where R is H. (See SX2 2
2003, examples 2-4 and structures depicted therein).
11. When the intermediate compounds of examples 5, 6 and 7 were employed in examples 2, 3
and 4, the stated result was not a preferred heterocyclic compound of the ‘146 patent. Examples 5, 6
and 7 describe the preparation of an intermediate compound that possesses an E moiety where E is N-
R and where R is H. (SX 2003, examples 5-7 and structures depicted therein). The compounds of2 2
examples 5, 6, and 7 were used in examples 2, 3 and 4 as follows:
(1) An intermediate compound of example 5 (5-methoxy-2-ntiroimino-hexahydro-1,3,5-
triazine) was reacted with 2-chloro-5-chloromethyl-pyridine in example 4. The resulting “desired”
compound was not a preferred compound of the invention.
(2) An intermediate compound of example 6 (5-methyl-2-nitroimino-hexahydro-1,3,5-
triazine) was reacted with 2-chloro-5-chloromethyl-pyridine in example 2. The resulting “desired”
compound was not a preferred compound of the invention.
(3) An intermediate compound of example 7 (5-methyl-2-cyanoimino-hexahydro-1,3,5-
triazine) was reacted with 5-chloro-2-chloromethylpyridine in example 3. The resulting “desired”
compound was not a preferred compound of the invention.
12. According to Shiokawa ‘146, compounds that can be prepared in analogous reactions to those
of examples 1-4 are depicted in Table 1. (SX 2003, col. 8, lines 58-61). Table 1 depicts the
structures of forty compounds, four of which were those obtained in examples 1-4. Not one of the
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