Appeal No. 2000-0634 Application No. 08/274,942 crosslinking energy in the process/apparatus of Clark would have been obvious to one of ordinary skill. Thus, we uphold the Examiner’s rejection of claim 5. Because there is substantial evidence to support the Examiner’s determination of a prima facie case of obviousness over each of the applied prior art references, the burden of proof was properly shifted to the appellants to rebut the prima facie case by presenting persuasive argument or evidence (e.g., unexpected results). In re Mayne, 104 F.3d 1339, 1343, 41 USPQ2d 1451, 1455 (Fed. Cir. 1997). (“With a factual foundation for its prima facie case of obviousness shown, the burden shifts to applicants to demonstrate that their claimed fusion proteins possess an unexpected property over the prior art.”). Appellants have not sufficiently rebutted the prima facie case of obviousness. CONCLUSION For the foregoing reasons and those set forth in the Answer, based on the totality of the record, we determine that the preponderance of evidence weighs in favor of obviousness, giving due weight to Appellants arguments. Accordingly, the Examiner’s rejections under 35 U.S.C. § 103(a) are affirmed. The rejection of claims 1 to 4, 8 to 40, 42 to 61 and 63 to 81 under 35 U.S.C. § 103(a) as obvious over Clark is affirmed. The rejection of claim 5 under 35 U.S.C. § 103(a) as obvious over the combination of Clark and Fogarty is affirmed. -8-Page: Previous 1 2 3 4 5 6 7 8 9 10 NextLast modified: November 3, 2007