Appeal No. 2001-0288 Page 3
Application No. 08/277,031
Yasumori et al. (Yasumori ‘89), “Expression of a human P-450IIC gene in yeast
cells using galactose-inducible expression system,” Molecular Pharmacology,
Vol. 35, pp. 443-449 (1989)
Eugster et al. (Eugster), “Constitutive and inducible expression of human
cytochrome P450IA1 in yeast Saccharomyces cerevisiae: an alternative enzyme
source for in vitro studies,” Biochemical and Biophysical Research
Communications, Vol. 172, No. 2, pp. 737-744 (1990)
Renaud et al. (Renaud), “Expression of human liver cytochrome P450 IIIA4 in
yeast,” European J. Biochemistry, Vol. 194, pp. 889-896 (1990)
Sakaki et al. (Sakaki), “Expression of bovine cytochrome P450c21 and its fused
enzymes with yeast NADPH-cytochrome P450 reductase in Saccharomyces
cerevisiae,” DNA and Cell Biology, Vol. 9, pp. 603-614 (1990)
Bligh et al. (Bligh), “Production of cytochrome P450 reductase yeast-rat hybrid
proteins in Saccharomyces cerevisiae,” Gene, Vol. 110, pp. 33-39 (1992)
Ellis et al. (Ellis), “Catalytic activities of human debrisoquine 4-hydroxylase
cytochrome P450 (CYP2D6) expressed in yeast,” Biochemical Pharmacology,
Vol. 44, No. 4, pp. 617-620 (1992)
Paolini et al. (Paolini), “Wide spectrum detection of precarcinogens in short-term
bioassays by simultaneous superinduction of multiple forms of cytochrome P450
isoenzymes,” Carcinogenesis, Vol. 12, No. 5, pp. 759-766 (1991)
GROUNDS OF REJECTION
Claims 1-5, 8, 9, 11, 13 and 14 stand rejected under 35 U.S.C. § 103 as
being unpatentable over Crespi, Sakaki, Yasumori ‘89 and Paolini in view of
Wolf, Yasumori ‘87 and Yabusaki.
Claims 6 and 7 stand rejected under 35 U.S.C. § 103 as being
unpatentable over Crespi, Sakaki, Yasumori ‘89 and Paolini in view of Wolf,
Yasumori ‘87 and Yabusaki and further in view of Ellis, Bligh and Eugster.
Claims 10 and 12 stand rejected under 35 U.S.C. § 103 as being
unpatentable over Crespi, Sakaki, Yasumori ‘89 and Paolini in view of Wolf,
Yasumori ‘87 and Yabusaki and further in view of Renaud.
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