Appeal No. 2001-0531 Page 2
Application No. 08/216,592
(b) assaying for expression of the reporter sequence, wherein
the host cell, organism, or cell-free extract has been altered
to express one or more dimmers comprising two subunits,
wherein one of the subunits is a retinoic acid receptor (RAR)
or a thyroid receptor (TR) and the other subunit is a retinoid
X receptor (RXR).
The examiner relies on the following references:
Hamada et al. (Hamada), “H-2RIIBP, A Member of the Nuclear Hormone
Receptor Superfamily that Binds to Both the Regulatory Element of Major
Histocompatibility Class I genes and the Estrogen Response Element,”
Proc. Natl. Acad. Sci. USA, Vol. 86, pp. 8289-8293 (1989)
Mangelsdorf et al. (Mangelsdorf), “Nuclear Receptor that Identifies a Novel
Retinoic Acid Response Pathway,” Nature, Vol. 345 pp. 224-229 (1990)
Glass et al. (Glass), “Positive and Negative Regulation of Gene Transcription by
a Retinoic Acid-Thyroid Hormone Receptor Heterodimer,” Cell , Vol. 59
pp. 697-708 (1989)
Yu et al. (Yu), “RXRß: A Coregulator that Enhances Binding of Retinoic Acid,
Thyroid Hormone, and Vitamin D Receptors to Their Cognate Response
Elements,” Cell, Vol. 67 pp. 1251-1266 (1991)
Claims 5, 29, 32, 34, and 46-48 stand rejected under 35 U.S.C. § 103 as
obvious in view of the combined disclosures of Glass and Mangelsdorf.
Claims 5, 32, 46, and 48 stand rejected under 35 U.S.C. § 102(a) as
anticipated by Yu.
Claims 5, 29, 34, and 47 stand rejected under 35 U.S.C. § 103 as obvious
in view of Yu.
Claims 31 and 37 stand rejected under 35 U.S.C. § 103 as obvious in view
of the combined disclosures of Yu and Hamada.
We reverse all of the rejections.
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