Appeal No. 2001-0758 Page 2
Application No. 08/919,477
1. An aminopolycarboxylate-appended peptide useful for radioiodinating an
antibody, comprising:
(a) a peptide that comprises at least one D-tyrosine or tyramine, an amino
terminus, a carboxy terminus formed from a D-lysine and no contiguous L-amino acids
between the D-tyrosine or tyramine and the carboxy terminus;
(b) an aminopolycarboxylate conjugated via one of its carboxylic acid groups to
the peptide via an ,-amino group of the D-lysine to form an aminopolycarboxylate-
appended peptide; and
(c) a linker group for covalently binding said aminopolycarboxylate-appended
peptide to an antibody.
2. The aminopolycarboxylate-appended peptide of claim 1, further comprising a
radioiodine atom covalently bound to the D-tyrosine or tyramine residue.
7. Tha aminopolycarboxylate-appended peptide of claim 1, wherein said
aminopolycarboxylate is selected from the group consisting of nitrilotriacetic acid,
EDTA, DTPA, TTHA, and backbone-substituted derivatives of nitrilotriacetic acid,
EDTA, DTPA, TTHA.
8. An aminopolycarboxylate-appended peptide useful for radioiodinating an
antibody, comprising:
(a) a peptide that comprises at least one D-tyrosine or tyramine, an amino
terminus, a carboxy terminus formed from a D-amino acid and no contiguous L-amino
acids between the D-tyrosine or tyramine and the carboxy terminus;
(b) an aminopolycarboxylate conjugated via one of its amino groups to the
peptide via an amide bind to a peptide carboxylic acid group or via a thiourea bond to a
peptide amino acid residue to form an aminopolycarboxylate-appended peptide; and
(c) a linker group for covalently binding said aminopolycarboxylate-appended
peptide to an antibody.
19. The aminopolycarboxylate-appended peptide of claim 1, wherein said linker
is selected from the group consisting of an amino group, imidate group, isothiocyanate
group, maleimide group and halo-acetamide group.
The references relied on by the examiner are:
Barbet et al. (Barbet) 5,274,076 Dec. 28, 1993
Matthews et al (Matthews) 5,273,738 Dec. 28, 1993
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