Appeal No. 2001-0759
Application 08/809,186
14. A method of inhibiting proliferation of cells which comprise the steps of :
(a) obtaining isolated Vpr protein or a functional fragment thereof; and
(b) contacting cells with an amount of said Vpr protein or a functional fragment
thereof effective to inhibit cell proliferation, wherein said cells are T cells and/or B cells
and/or monocytes.
The prior art references relied upon by the examiner are:
Levy et al (Levy), “Induction of Cell Differentiation by Human Immunodeficiency Virus 1
vpr,” Cell, Vol 72, No. 4, pp. 541-550 (1993)
Bybee et al (Bybee), “Cell Cycle Regulation,” Blood Reviews, Vol. 5, No. 3, pp. 177-192
(1991)
Scott et al. (Scott), “Regulation of differentiation, proliferation, and cancer suppressor
activity,” Internati. J. Develop. Biol., Vol. 37, No. 1, pp. 67-74 (1993)
Wiedermann, et al. (Wiedermann), “Regulation of Myeloid Phagocyte Development and
Function by Growth Hormone: A Review,” J. Pediatr. Endocrin., Vol. 6, No. 1, pp. 85-91
(1993)
Murphy et al. (Murphy), “Molecular Regulation of Neural Crest Development,” Molec.
Neurobiol., Vol. 7, No. 2, pp. 111-135 (1993)
Johnson, “ Negative Regulators of Cell Proliferation,” Pharmacol. Therap., Vol. 62, No.
1-2, pp. 247-265 (1994)
Benet et al. (Benet), “Pharmacokinetics: The Dynamics of Drug Absorption, Distribution
and Elimination,” Goodman and Gilman’s the Pharmacological Basis of Therapeutics,
Goodman et al, Eds., Pergamon Press, New York, pp. 3-32 (1990)
Grounds of Rejection
2
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